Turkije: Umts en oxidatieve stress in rattenharten, beschermende werking selenium en L-carnitine.
donderdag, 03 maart 2011 - Categorie: Onderzoeken
Bron: Biological Trace Element Research 2011 Mar 1.
Selenium and L: -Carnitine Reduce Oxidative Stress in the Heart of Rat Induced by 2.45-GHz Radiation from Wireless Devices.
Türker Y, Nazrolu M, Gümral N, Celik O, Saygn M, Cömlekçi S, Flores-Arce M.
Department of Cardiology, Medical Faculty, Suleyman Demirel University, Isparta, Turkey.
The aim of this study was to investigate the possible protective role of selenium and L: -carnitine on oxidative stress induced by 2.45-GHz radiation in heart of rat.
For this purpose, 30 male Wistar Albino rats were equally divided into five groups namely controls, sham controls, radiation-exposed rats, radiation-exposed rats treated with intraperitoneal injections of sodium selenite at a dose of 1.5 mg/kg/day, and radiation-exposed rats treated with intraperitoneal injections of L: -carnitine at a dose of 1.5 mg/kg/day.
Except for the controls and sham controls, the animals were exposed to 2.45-GHz radiation during 60 min/day for 28 days. The lipid peroxidation (LP) levels were higher in the radiation-exposed groups than in the control and sham control groups. The lipid peroxidation level in the irradiated animals treated with selenium and L: -carnitine was lower than in those that were only exposed to 2.45-GHz radiation.
The concentrations of vitamins A, C, and E were lower in the irradiated-only group relative to control and sham control groups, but their concentrations were increased in the groups treated with selenium- and L: -carnitine.
The activity of glutathione peroxidase was higher in the selenium-treated group than in the animals that were irradiated but received no treatment. The erythrocyte-reduced glutathione and ?-carotene concentrations did not change in any of the groups.
In conclusion, 2.45-GHz electromagnetic radiation caused oxidative stress in the heart of rats. There is an apparent protective effect of selenium and L: -carnitine by inhibition of free radical formation and support of the antioxidant redox system.
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