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Bloed-hersenbarrière, lek door RF straling
Bron: betweenrockandhardplace.wordpress.com/2015/05/18/cell-phones-and-blood-brain-barrier-chinese-scientists-confirm-findings-of-swedish-salford-group/ .
18 mei 2015
Een serie publicaties over lekkage van de bloed-hersenbarrière veroorzaakt door RF straling, met onder meer een nieuw artikel in:
Exposure to 900 MHz electromagnetic fields activates the mkp-1/ERK pathway and causes blood-brain barrier damage and cognitive impairment in rats.
Brain Res. 2015 Mar 19;1601:92-101. doi: 10.1016/j.brainres.2015.01.019. Epub 2015 Jan 15.
Tang J1, Zhang Y1, Yang L1, Chen Q1, Tan L1, Zuo S1, Feng H1, Chen Z1, Zhu G2.
1Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
2Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China. Electronic address: firstname.lastname@example.org.
With the rapid increase in the number of mobile phone users, the potential adverse effects of the electromagnetic field radiation emitted by a mobile phone has become a serious concern. This study demonstrated, for the first time, the blood-brain barrier and cognitive changes in rats exposed to 900 MHz electromagnetic field (EMF) and aims to elucidate the potential molecular pathway underlying these changes. A total of 108 male Sprague-Dawley rats were exposed to a 900 MHz, 1 mW/cm(2) EMF or sham (unexposed) for 14 or 28 days (3h per day). The specific energy absorption rate (SAR) varied between 0.016 (whole body) and 2 W/kg (locally in the head). In addition, the Morris water maze test was used to examine spatial memory performance determination. Morphological changes were investigated by examining ultrastructural changes in the hippocampus and cortex, and the Evans Blue assay was used to assess blood brain barrier (BBB) damage. Immunostaining was performed to identify heme oxygenase-1 (HO-1)-positive neurons and albumin extravasation detection. Western blot was used to determine HO-1 expression, phosphorylated ERK expression and the upstream mediator, mkp-1 expression. We found that the frequency of crossing platforms and the percentage of time spent in the target quadrant were lower in rats exposed to EMF for 28 days than in rats exposed to EMF for 14 days and unexposed rats. Moreover, 28 days of EMF exposure induced cellular edema and neuronal cell organelle degeneration in the rat. In addition, damaged BBB permeability, which resulted in albumin and HO-1 extravasation were observed in the hippocampus and cortex. Thus, for the first time, we found that EMF exposure for 28 days induced the expression of mkp-1, resulting in ERK dephosphorylation. Taken together, these results demonstrated that exposure to 900 MHz EMF radiation for 28 days can significantly impair spatial memory and damage BBB permeability in rat by activating the mkp-1/ERK pathway.
Copyright © 2015 Elsevier B.V. All rights reserved.
Blood brain barrier; Electromagnetic field; albumin extravasation; mkp-1/ERK pathway; spatial memory
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