StopUMTS Logo
how to get rid of moles 
Zoeken
   
Voorlichting
23/01/18Meetspecialisten, afsc
22/01/18ICNIRP Guidelines 1998, E
Artikelen
23/01/185G - From blankets to bul
23/01/18Groundbreaking Study Show
22/01/18WiFi In Schools
22/01/18Literatuur over gezondhei
19/01/18Home networking explained
14/01/18Can Cell Phones Cause Fem
Berichten Nederland
22/01/18Computers in een school h
20/01/18Mobiel internetten explod
20/01/18Voorschoten: D66: bescher
18/01/18Unlimited 4G voor thuis g
17/01/18Vergaderlocatie / cursusr
Berichten België
18/01/18Aartselaar / Reet: Buren
10/01/18Vereniging ElektroHyperSe
Berichten Internationaal
15/01/18Frankrijk pakt belabberde
12/01/18Oostenrijk: Richtlijnen v
12/01/18Frankreich verordnet Stra
09/01/18USA: CDPH Cell Phone Safe
Ervaringen | Appellen/oproepen
15/01/18Ziekmakende ervaringen me
12/01/18Soms is tinnitus geen tin
12/01/18Bijnier probleem met smar
Onderzoeken
20/01/18Iron deposition in rabbit
03/01/18EMFs + Wildlife
29/12/17Radiofrequency EMFs and H
Veel gestelde vragen
13/05/17Vakantie? Witte zo
10/07/16Zeven veel gestelde vrage
Juridische informatie
23/01/18Reeks publicaties op juri
23/01/18Juridisch advies en begel
19/01/18Afspraken voor beterere t
Oproepen
10/12/17Haarlem: Raadsmarkt ZENDM
11/11/17Cursus ‘Straling meten
29/10/17Petitie: Geen uitbreiding
Folders
10/09/17Brochures, folders, websi
29/04/16USA: Meer dan 50 tips voo
Briefwisselingen | Archief: 2008, 2005
19/01/18Brief aan Agentschap Tele
18/01/18Brief naar de gemeente Ut
Illustraties
 Algemeen
 Fotoalbum zendmasten
 Wetenschappelijke illustraties
Korea: Effrecten van LF EMV op stam cellen in beenmerg    
Ga naar overzicht berichten in: Onderzoeken

Korea: Effrecten van LF EMV op stam cellen in beenmerg
donderdag, 05 december 2013 - Dossier: Algemeen


Bron: www.ncbi.nlm.nih.gov/pubmed/23970408?dopt=Abstract .
1 aug. 2013


Exp Biol Med (Maywood). 2013 Aug 1;238(8):923-31.

Extremely low-frequency electromagnetic fields induce neural differentiation in bone marrow derived mesenchymal stem cells.

Kim HJ, Jung J, Park JH, Kim JH, Ko KN, Kim CW.

School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Korea.

Abstract
Extremely low-frequency electromagnetic fields (ELF-EMF) affect numerous biological functions such as gene expression, cell fate determination and even cell differentiation. To investigate the correlation between ELF-EMF exposure and differentiation, bone marrow derived mesenchymal stem cells (BM-MSCs) were subjected to a 50-Hz electromagnetic field during in vitro expansion. The influence of ELF-EMF on BM-MSCs was analysed by a range of different analytical methods to understand its role in the enhancement of neural differentiation. ELF-EMF exposure significantly decreased the rate of proliferation, which in turn caused an increase in neuronal differentiation. The ELF-EMF-treated cells showed increased levels of neuronal differentiation marker (MAP2), while early neuronal marker (Nestin) was down-regulated. In addition, eight differentially expressed proteins were detected in two-dimensional electrophoresis maps, and were identified using ESI-Q-TOF LC/MS/MS. Among them, ferritin light chain, thioredoxin-dependent peroxide reductase, and tubulin β-6 chain were up-regulated in the ELF-EMF-stimulated group. Ferritin and thioredoxin-dependent peroxide reductase are involved in a wide variety of functions, including Ca(2+) regulation, which is a critical component of neurodegeneration. We also observed that the intracellular Ca(2+) content was significantly elevated after ELF-EMF exposure, which strengthens the modulatory role of ferritin and thioredoxin-dependent peroxide reductase, during differentiation. Notably, western blot analysis indicated significantly increased expression of the ferritin light chain in the ELF-EMF-stimulated group (0.60 vs. 1.08; P < 0.01). These proteins may help understand the effect of ELF-EMF stimulation on BM-MSCs during neural differentiation and its potential use as a clinically therapeutic option for treating neurodegenerative diseases.

KEYWORDS:
BM-MSCs, Ca2+ regulation, Extremely low-frequency electromagnetic fields, ferritin, neural differentiation
PMID: 23970408 (PubMed - in process)


Ga terug naar het hoofdmenu
Afdrukken | Vragen | RSS | Disclaimer